Article
Tumor Mutational Burden as a Biomarker of Immunotherapy Response: An Immunogram Approach in Onco-immunology.
Current molecular medicine - 1 Jan 2024
Ansari Afzal, Ray Suman Kumar, Sharma Mukul, Rawal Rakesh, Singh Pushpendra
Abstract excerpt
Immune checkpoint inhibitors have revolutionized cancer treatment by allowing T cells to reactivate. Tumor mutational burden (TMB) is a biomarker that has emerged as a viable diagnostic for locating patients who would benefit from immunotherapy in particular cancer types. Greater neo-antigens mean more opportunities for T cell identification, and TMB is clinically linked to better immune checkpoint inhibitors....
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