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Article

The synthesis and bioactivity of pyrrolo[2,3-d]pyrimidine derivatives as tyrosine kinase inhibitors for NSCLC cells with EGFR mutations.

European journal of medicinal chemistry - 15 Nov 2021

Xia Zhenqiang, Huang Ridong, Zhou Xinglong, Chai Yingying, Chen Hai, Ma Lingling, Yu Quanwei, Li Ying, Li Weimin, He Yang

Abstract excerpt

EGFR mutations are an ongoing challenge in the treatment of NSCLC, and demand continuous updating of EGFR TKI drug candidates. Pyrrolopyrimidines are one group of versatile scaffolds suitable for tailored drug development. However not many precedents of this type of pharmacophore have been investigated in the realm of third generation of covalent EGFR-TKIs. Herein, a series of pyrrolo[2,3-d]pyrimidine derivatives...

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PMID: 34315040
DOI: 10.1016/j.ejmech.2021.113711

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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