Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The combination of TRAIL and the Smac mimetic LCL-161 induces an irreversible phenotypic change of MCF-7 breast cancer cells.

Experimental and molecular pathology - 1 Apr 2022

Granqvist Victoria, Holmgren Christian, Larsson Christer

Abstract excerpt

INTRODUCTION: Breast cancer is the most common malignancy affecting women. Although the prognosis generally is good, a substantial number of patients still suffer from relapse, emphasizing the need for novel treatments. Smac mimetics were developed to facilitate cell death by blocking inhibitor of apoptosis proteins (IAPs). It has been suggested that TNF-related apoptosis inducing ligand (TRAIL) can be used...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Breast Neoplasms
Share to Caspases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inhibitor of Apoptosis Proteins

Share to MCF-7 Cells

Share to Neoplasm Recurrence, Local

Share to NF-kappa B

Share to TNF-Related Apoptosis-Inducing Ligand

Source

Identifiers

PMID: 35007560
DOI: 10.1016/j.yexmp.2021.104739

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The combination of TRAIL and the Smac mimetic LCL-161 induces an irreversible phenotypic change of MCF-7 breast cancer cells.PMID 35007560Read ↗

Inhibition of IAPs induces programmed cell death and inflammatory signaling in patient-derived metastatic breast cancer organoidsSemantic proximity Read ↗

RNA-seq Analysis Reveals Upregulation in ER -Stress-Related Genes Upon LCL-161 Treatment in SH-SY5Y Human Neuroblastoma CellsSemantic proximity Read ↗

The SMAC mimetic BV6 induces cell death and sensitizes different cell lines to TNF-α and TRAIL-induced apoptosisSemantic proximity Read ↗

Molecular Pathways: Targeting Death Receptors and Smac MimeticsSemantic proximity Read ↗

Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screeningSemantic proximity Read ↗

CLL cells are resistant to smac mimetics because of an inability to form a ripoptosome complex.Semantic proximity Read ↗

MicroRNA-21 (miR-21) in breast cancer: From apoptosis dysregulation to therapeutic opportunitiesSemantic proximity Read ↗

A 71-Gene Signature of TRAIL Sensitivity in Cancer CellsSemantic proximity Read ↗

The Second Mitochondrial Activator of Caspases (SMAC) regulates growth, inflammation and mitochondrial integrity in cancer cellsSemantic proximity Read ↗

Addition of 5-fluorouracil to doxorubicin-paclitaxel sequence increases caspase-dependent apoptosis in breast cancer cell linesSemantic proximity Read ↗

The TRAIL of oncogenes to apoptosisSemantic proximity Read ↗

Smac mimetics and TRAIL cooperate to induce MLKL-dependent necroptosis in Burkitt's lymphoma cell linesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.