Article
The immune pathogenesis of scleroderma: context is everything.
Current rheumatology reports - 1 Jan 2013
Greenblatt Matthew B, Aliprantis Antonios O
Abstract excerpt
The fundamental mechanisms that drive the pathogenesis of systemic sclerosis (SSc) remain elusive, despite over 50 years of investigation. Here, we review recent progress in the understanding of the immunopathogenesis of SSc. In particular, we consider interleukin-13 (IL13), and its upstream and downstream pathways, as an example of an immune system-derived mediator involved in fibrotic and vascular pathology....
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