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Apoptosis of tumor infiltrating effector TIM-3+CD8+ T cells in colon cancer

23 Oct 2015

Abstract excerpt

TIM-3 functions to enforce CD8+ T cell exhaustion, a dysfunctional state associated with the tolerization of tumor microenvironment. Here we report apoptosis of IFN-γ competent TIM-3+ population of tumor-infiltrating CD8+ T cells in colon cancer. In humans suffering from colorectal cancer, TIM-3+ population is higher in cancer tissue-resident relative to peripheral blood CD8+ T cells. Both the TIM-3+ and TIM-3-...

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PMID: 26493689
DOI: 10.1038/srep15659

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