Article
The profibrotic and senescence phenotype of old lung fibroblasts is reversed or ameliorated by genetic and pharmacological manipulation of Slc7a11 expression.
American journal of physiology. Lung cellular and molecular physiology - 1 Mar 2022
Ritzenthaler Jeffrey D, Torres-Gonzalez Edilson, Zheng Yuxuan, Zelko Igor N, van Berkel Victor, Nunley David R, Kidane Biniam, Halayko Andrew J, Summer Ross, Watson Walter H, Roman Jesse
Abstract excerpt
Increased senescence and expression of profibrotic genes in old lung fibroblasts contribute to disrepair responses. We reported that primary lung fibroblasts from old mice have lower expression and activity of the cystine transporter Slc7a11/xCT than cells from young mice, resulting in changes in both the intracellular and extracellular redox environments. This study examines the hypothesis that low Slc7a11...
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