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Transcriptional activation of FN1 and IL11 by HMGA2 promotes the malignant behavior of colorectal cancer

10 Mar 2016

Abstract excerpt

Colorectal cancer (CRC) is the second leading cause of cancer deaths worldwide, and metastasis is the principle reason for its poor prognosis. Overexpression of high-mobility gene group A2 (HMGA2) contributes to the aggressiveness of CRC. However, the underlying molecular mechanism of its overexpression is still elusive. In this study, we showed that ectopic expression of HMGA2 significantly enhanced cell...

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Cancer-related molecular mechanisms research
Cell Adhesion Molecules Research
RNA Research and Splicing

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26964871
DOI: 10.1093/carcin/bgw029

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