Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Idiopathic chronic pancreatitis treated with ivacaftor in a CFTR carrier with methylmalonic acidemia.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Jul 2022

Tang Tin-Yun, Cruz Vincent B, Konczal Laura L

Abstract excerpt

CFTR mutation carriers, numbering 1 in 25 among Caucasians, have an increased risk of developing chronic pancreatitis due to the underlying dysfunction of ion channels created by the mutant allele. Carriers do not frequently manifest disease due to the remaining wild-type CFTR protein sufficiently maintaining normal pancreatic homeostasis. However, additional risk factors for pancreatitis, such as organic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Metabolism, Inborn Errors
Share to Aminophenols

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chloride Channel Agonists

Share to Cystic Fibrosis

Share to Cystic Fibrosis Transmembrane Conductance Regulator

Share to Mutation

Share to Pancreatitis, Chronic

Share to Quinolones

Source

Identifiers

PMID: 34974990
DOI: 10.1016/j.jcf.2021.12.013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Idiopathic chronic pancreatitis treated with ivacaftor in a CFTR carrier with methylmalonic acidemia.PMID 34974990Read ↗

Acute pancreatitis in pancreatic-insufficient cystic fibrosis patients treated with CFTR modulators.Semantic proximity Read ↗

Differential Expression and Microsystem Physiology Reveal Predominant and Drug Reversible CFTR-Related Defects in Idiopathic PancreatitisSemantic proximity Read ↗

CFTR function is impaired in a subset of patients with pancreatitis carrying rare CFTR variants.Semantic proximity Read ↗

Functional characterisation of the CFTR mutations M348V and A1087P from patients with pancreatitis suggests functional interaction between CFTR monomers.Semantic proximity Read ↗

Celiac Disease in Patients With Cystic Fibrosis on Ivacaftor: A Case Series.Semantic proximity Read ↗

Cystic fibrosis presenting as acute pancreatitis and obstructive azoospermia in a young adult male with a novel mutation in the CFTR gene.Semantic proximity Read ↗

Persistent recovery of pancreatic function in patients with cystic fibrosis after ivacaftor.Semantic proximity Read ↗

CFTR modulators increase risk of acute pancreatitis in pancreatic insufficient patients with cystic fibrosis.Semantic proximity Read ↗

Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis.Semantic proximity Read ↗

Mislocalization of CFTR expression in acute pancreatitis and the beneficial effect of VX-661 + VX-770 treatment on disease severity.Semantic proximity Read ↗

Combination of CFTR gene mutation and autoimmune pancreatitis presenting as necrotizing pancreatitis.Semantic proximity Read ↗

A case report of CFTR modulator administration via carrier mother to treat meconium ileus in a F508del homozygous fetus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.