Article
CFTR modulators increase risk of acute pancreatitis in pancreatic insufficient patients with cystic fibrosis.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Jul 2022
Gould Michelle J, Smith Haley, Rayment Jonathan H, Machida Helen, Gonska Tanja, Galante Gary J
Abstract excerpt
Patients with pancreatic insufficient cystic fibrosis rarely develop acute pancreatitis due to insufficient acinar reserve. We describe a series of five patients under the age of 18 (range 8-16 years) with pancreatic insufficient cystic fibrosis who developed a phenotype in keeping with acute pancreatitis following initiation of CFTR modulator therapy. This occurred at a median of 30 months following CFTR...
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