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Article

A case report of CFTR modulator administration via carrier mother to treat meconium ileus in a F508del homozygous fetus.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Jul 2022

Szentpetery Sylvia, Foil Kimberly, Hendrix Sara, Gray Sue, Mingora Christina, Head Barbara, Johnson Donna, Flume Patrick A

Abstract excerpt

We report elexacaftor-tezacaftor-ivacaftor (ETI) treatment of a F508del carrier who was pregnant with a F508del homozygous fetus. At 23-weeks gestation meconium ileus (MI) was evident on ultrasound including dilated, hyperechoic bowel, which persisted on subsequent imaging. Through shared decision-making, the mother began ETI at 32 weeks with intent to treat fetal MI. The ultrasound findings persisted at...

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Identifiers

PMID: 35422395
DOI: 10.1016/j.jcf.2022.04.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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