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Article

Unraveling the complex interplay between genes, environment, and climate in ALS.

EBioMedicine - 1 Jan 2022

Vasta Rosario, Chia Ruth, Traynor Bryan J, Chiò Adriano

Abstract excerpt

Various genetic and environmental risk factors have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). Despite this, the cause of most ALS cases remains obscure. In this review, we describe the current evidence implicating genetic and environmental factors in motor neuron degeneration. While the risk exerted by many environmental factors may appear small, their effect could be magnified...

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Identifiers

PMID: 34974309
DOI: 10.1016/j.ebiom.2021.103795
PMCID: PMC8728044

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