Molecular basis of autosomal recessive chronic granulomatous disease in iran.

Abstract excerpt

INTRODUCTION: Chronic granulomatous disease (CGD) is a rare inherited condition resulting from mutations in the genes that encode the proteins of the NADPH oxidase enzyme in phagocytes, rendering these cells incapable of killing invading pathogens. MATERIALS AND METHODS: Patients subtypes are determined by neutrophil functional assays and immunoblotting. Although defects in the X-chromosome-linked gp91-phox...

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