Article
A Novel Genetic Variation in NCF2, the Core Component of NADPH Oxidase, Contributes to the Susceptibility of Tuberculosis in Western Chinese Han Population.
DNA and cell biology - 1 Jan 2020
Jiao Lin, Song Jiajia, Ding Liu, Liu Tangyuheng, Wu Tao, Zhang Jingwei, Bai Hao, Chen Hao, Zhao Zhenzhen, Ying Binwu
Abstract excerpt
Mycobacterium tuberculosis (Mtb) is the causative agent of the disease tuberculosis (TB). Macrophages eliminate the Mtb, delivering it to the degradative, phagolysosomal compartment for degradation, in which reactive oxygen species generated by nicotinamide adenine dinucleotide phosphate oxidase (NADPHO) plays an important role. In our study, we aimed at investigating the association of polymorphisms in...
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