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Article

Spatial and Phenotypic Heterogeneity of ILC Subsets in Mouse Lung Under Type 2 Inflammatory Conditions.

European journal of immunology - 1 Jun 2026

Kroh Sandy, Pascual-Reguant Anna, Manukyan Artür, Uecker Ralf, Günther Robert, Philipsen Lars, Koehler Ralf, Mex Peggy, Landthaler Markus, Niesner Raluca A, Hauser Anja E

Abstract excerpt

As key regulators of mucosal immunity, innate lymphoid cells (ILCs) are involved in tissue homeostasis, inflammation, and repair. Studying ILCs within their native microenvironment remains challenging due to the low abundance of these tissue-resident immune cells. Here, we applied cyclic multiplex immunofluorescence, namely multiepitope ligand cartography (MELC), in a systemic IL-33-induced type 2 inflammation...

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PMID: 42307017
DOI: 10.1002/eji.70223
PMCID: PMC13273930

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