Article
Airway remodelling and inflammation in asthma are dependent on the extracellular matrix protein fibulin-1c.
The Journal of pathology - 1 Dec 2017
Liu Gang, Cooley Marion A, Nair Prema M, Donovan Chantal, Hsu Alan C, Jarnicki Andrew G, Haw Tatt Jhong, Hansbro Nicole G, Ge Qi, Brown Alexandra C, Tay Hock, Foster Paul S, Wark Peter A, Horvat Jay C, Bourke Jane E, Grainge Chris L, Argraves W Scott, Oliver Brian G, Knight Darryl A, Burgess Janette K, Hansbro Philip M
Abstract excerpt
Asthma is a chronic inflammatory disease of the airways. It is characterized by allergic airway inflammation, airway remodelling, and airway hyperresponsiveness (AHR). Asthma patients, in particular those with chronic or severe asthma, have airway remodelling that is associated with the accumulation of extracellular matrix (ECM) proteins, such as collagens. Fibulin-1 (Fbln1) is an important ECM protein that...
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