Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IFN-γ‒Induced APOBEC3B Contributes to Merkel Cell Polyomavirus Genome Mutagenesis in Merkel Cell Carcinoma

28 Dec 2021

Abstract excerpt

Merkel cell polyomavirus (MCPyV) is the causative agent of an aggressive skin tumor, Merkel cell carcinoma. The viral genome is integrated into the tumor genome and harbors nonsense mutations in the helicase domain of large T antigen. However, the molecular mechanisms by which the viral genome gains the tumor-specific mutations remain to be elucidated. Focusing on host cytosine deaminases APOBEC3s, we find that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Full-Duplex Wireless Communications
Share to Plant Virus Research Studies
Share to Polyomavirus and related diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34968501
DOI: 10.1016/j.jid.2021.12.019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IFN-γ‒Induced APOBEC3B Contributes to Merkel Cell Polyomavirus Genome Mutagenesis in Merkel Cell CarcinomaPMID 34968501Read ↗

Oncogenic Merkel Cell Polyomavirus T Antigen Truncating Mutations are Mediated by APOBEC3 Activity in Merkel Cell Carcinoma.Semantic proximity Read ↗

Merkel Cell Polyomavirus Exhibits Dominant Control of the Tumor Genome and Transcriptome in Virus-Associated Merkel Cell CarcinomaSemantic proximity Read ↗

Merkel Cell Polyomavirus: Molecular Insights into the Most Recently Discovered Human Tumour VirusSemantic proximity Read ↗

Clonal Integration of a Polyomavirus in Human Merkel Cell CarcinomaSemantic proximity Read ↗

Functional Upregulation of the DNA Cytosine Deaminase APOBEC3B by PolyomavirusesSemantic proximity Read ↗

Merkel cell carcinoma: a virus-induced human cancer.Semantic proximity Read ↗

From Merkel Cell Polyomavirus Infection to Merkel Cell Carcinoma OncogenesisSemantic proximity Read ↗

Molecular Mechanisms of Merkel Cell Polyomavirus Transformation and ReplicationSemantic proximity Read ↗

Mutational landscape of MCPyV-positive and MCPyV-negative Merkel cell carcinomas with implications for immunotherapy.Semantic proximity Read ↗

Epigenetic Dysregulations in Merkel Cell Polyomavirus-Driven Merkel Cell CarcinomaSemantic proximity Read ↗

Merkel Cell Polyomavirus Gene Expression and Mutational Analysis of Large Tumor Antigen in Non-Merkel Cell Carcinoma Tumors of Iranian Patients.Semantic proximity Read ↗

Merkel Cell Polyomavirus: Oncogenesis in a Stable GenomeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.