Article
The SARS-CoV-2 Lambda variant exhibits enhanced infectivity and immune resistance.
Cell reports - 11 Jan 2022
Kimura Izumi, Kosugi Yusuke, Wu Jiaqi, Zahradnik Jiri, Yamasoba Daichi, Butlertanaka Erika P, Tanaka Yuri L, Uriu Keiya, Liu Yafei, Morizako Nanami, Shirakawa Kotaro, Kazuma Yasuhiro, Nomura Ryosuke, Horisawa Yoshihito, Tokunaga Kenzo, Ueno Takamasa, Takaori-Kondo Akifumi, Schreiber Gideon, Arase Hisashi, Motozono Chihiro, Saito Akatsuki, Nakagawa So, Sato Kei
Abstract excerpt
SARS-CoV-2 Lambda, a variant of interest, has spread in some South American countries; however, its virological features and evolutionary traits remain unclear. In this study, we use pseudoviruses and reveal that the spike protein of the Lambda variant is more infectious than that of other variants due to the T76I and L452Q mutations. The RSYLTPGD246-253N mutation, a unique 7-amino acid deletion in the N-terminal...
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