Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detection of minor variants in Mycobacterium tuberculosis whole genome sequencing data.

Briefings in bioinformatics - 17 Jan 2022

Goossens Sander N, Heupink Tim H, De Vos Elise, Dippenaar Anzaan, De Vos Margaretha, Warren Rob, Van Rie Annelies

Abstract excerpt

The study of genetic minority variants is fundamental to the understanding of complex processes such as evolution, fitness, transmission, virulence, heteroresistance and drug tolerance in Mycobacterium tuberculosis (Mtb). We evaluated the performance of the variant calling tool LoFreq to detect de novo as well as drug resistance conferring minor variants in both in silico and clinical Mtb next generation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins
Share to Gene Frequency

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

Share to INDEL Mutation

Share to Mycobacterium tuberculosis

Share to Polymorphism, Single Nucleotide

Share to Tuberculosis, Multidrug-Resistant

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 34962257
DOI: 10.1093/bib/bbab541
PMCID: PMC8769888

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detection of minor variants in Mycobacterium tuberculosis whole genome sequencing data.PMID 34962257Read ↗

Inclusion of minor alleles improves catalogue-based prediction of fluoroquinolone resistance in<i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

TBProfiler for automated calling of the association with drug resistance of variants in Mycobacterium tuberculosisSemantic proximity Read ↗

Detection of low-frequency resistance-mediating SNPs in next-generation sequencing data of Mycobacterium tuberculosis complex strains with binoSNP.Semantic proximity Read ↗

Evaluating the performance of tools used to call minority variants from whole genome short-read dataSemantic proximity Read ↗

Benchmarking the empirical accuracy of short-read sequencing across the<i>M. tuberculosis</i>genomeSemantic proximity Read ↗

Genomic sequence characteristics and the empiric accuracy of short-read sequencingSemantic proximity Read ↗

Cryptic Microheteroresistance Explains Mycobacterium tuberculosis Phenotypic ResistanceSemantic proximity Read ↗

Viral population analysis and minority-variant detection using short read next-generation sequencing.Semantic proximity Read ↗

Characterization of mutation spectra with ultra-deep pyrosequencing: application to HIV-1 drug resistance.Semantic proximity Read ↗

Control of artefactual variation in reported inter-sample relatedness during clinical use of a <i>Mycobacterium tuberculosis</i> sequencing pipelineSemantic proximity Read ↗

Control of Artifactual Variation in Reported Intersample Relatedness during Clinical Use of a Mycobacterium tuberculosis Sequencing Pipeline.Semantic proximity Read ↗

Reducing mapping reference and lineage bias in Mycobacterium tuberculosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.