Article
The rs429358 Locus in Apolipoprotein E Is Associated With Hepatocellular Carcinoma in Patients With Cirrhosis.
Hepatology communications - 1 May 2022
Innes Hamish, Nischalke Hans Dieter, Guha Indra Neil, Weiss Karl Heinz, Irving Will, Gotthardt Daniel, Barnes Eleanor, Fischer Janett, Ansari M Azim, Rosendahl Jonas, Lin Shang-Kuan, Marot Astrid, Pedergnana Vincent, Casper Markus, Benselin Jennifer, Lammert Frank, McLauchlan John, Lutz Philip L, Hamill Victoria, Mueller Sebastian, Morling Joanne R, Semmler Georg, Eyer Florian, von Felden Johann, Link Alexander, Vogel Arndt, Marquardt Jens U, Sulk Stefan, Trebicka Jonel, Valenti Luca, Datz Christian, Reiberger Thomas, Schafmayer Clemens, Berg Thomas, Deltenre Pierre, Hampe Jochen, Stickel Felix, Buch Stephan
Abstract excerpt
The host genetic background for hepatocellular carcinoma (HCC) is incompletely understood. We aimed to determine if four germline genetic polymorphisms, rs429358 in apolipoprotein E (APOE), rs2642438 in mitochondrial amidoxime reducing component 1 (MARC1), rs2792751 in glycerol-3-phosphate acyltransferase (GPAM), and rs187429064 in transmembrane 6 superfamily member 2 (TM6SF2), previously associated with...