A Rat Model of Post-Traumatic Stress Syndrome Causes Phenotype-Associated Morphological Changes and Hypofunction of the Adrenal Gland.

doi:10.3390/ijms222413235

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Article

A Rat Model of Post-Traumatic Stress Syndrome Causes Phenotype-Associated Morphological Changes and Hypofunction of the Adrenal Gland.

International journal of molecular sciences - 8 Dec 2021

Tseilikman Vadim, Komelkova Maria, Kondashevskaya Marina V, Manukhina Eugenia, Downey H Fred, Chereshnev Valerii, Chereshneva Margarita, Platkovskii Pavel, Goryacheva Anna, Pashkov Anton, Fedotova Julia, Tseilikman Olga, Maltseva Natalya, Cherkasova Olga, Steenblock Charlotte, Bornstein Stefan R, Ettrich Barbara, Chrousos George P, Ullmann Enrico

Abstract excerpt

BACKGROUND: Rats exposed to chronic predator scent stress mimic the phenotype of complex post-traumatic stress disorder (PTSD) in humans, including altered adrenal morphology and function. High- and low-anxiety phenotypes have been described in rats exposed to predator scent stress (PSS). This study aimed to determine whether these high- and low-anxiety phenotypes correlate with changes in adrenal histomorphology...

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PMID: 34948031
DOI: 10.3390/ijms222413235
PMCID: PMC8705403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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