Article
High and low anxiety phenotypes in a rat model of complex post-traumatic stress disorder are associated with different alterations in regional brain monoamine neurotransmission.
Psychoneuroendocrinology - 1 Jul 2020
Tseilikman Vadim, Komelkova Maria, Lapshin Maxim, Alliluev Anatoli, Tseilikman Olga, Karpenko Marina, Pestereva Nina, Manukhina Eugenia, Downey H Fred, Kondashevskaya Marina, Sarapultsev Alexey, Dremencov Eliyahu
Abstract excerpt
BACKGROUND: Repeated exposure to predator scent stress (PSS) has been used as an animal model of complex post-traumatic stress disorder (CPTSD). The aim of the current study was to assess brain monoamines and their primary metabolites concentrations in male Wistar rats (16 control, 19 exposed to chronic PSS). METHODS: Rats were exposed to PSS for ten days. Fourteen days later, the rats' anxiety index (AI) was...
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