Article
Current Status of Animal Models of Posttraumatic Stress Disorder: Behavioral and Biological Phenotypes, and Future Challenges in Improving Translation.
Biological psychiatry - 15 May 2018
Deslauriers Jessica, Toth Mate, Der-Avakian Andre, Risbrough Victoria B
Abstract excerpt
Increasing predictability of animal models of posttraumatic stress disorder (PTSD) has required active collaboration between clinical and preclinical scientists. Modeling PTSD is challenging, as it is a heterogeneous disorder with ≥20 symptoms. Clinical research increasingly utilizes objective biological measures (e.g., imaging, peripheral biomarkers) or nonverbal behaviors and/or physiological responses to...
Topics
- Animals
- Behavior, Animal
- Disease Models, Animal
- Extinction, Psychological
- Humans
- Mood Disorders
- Phenotype
- Stress Disorders, Post-Traumatic
- Translational Research, Biomedical