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Article

Humanized chondroitinase ABC sensitizes glioblastoma cells to temozolomide.

The journal of gene medicine - 1 Mar 2017

Jaime-Ramirez Alena Cristina, Dmitrieva Nina, Yoo Ji Young, Banasavadi-Siddegowda Yeshavanth, Zhang Jianying, Relation Theresa, Bolyard Chelsea, Wojton Jeffrey, Kaur Balveen

Abstract excerpt

BACKGROUND: Malignant gliomas (glioblastomas; GBMs) are extremely aggressive and have a median survival of approximately 15 months. Current treatment modalities, which include surgical resection, radiation and chemotherapy, have done little to prolong the lives of GBM patients. Chondroitin sulfate proteoglycans (CSPG) are critical for cell-cell and cell-extracellular matrix (ECM) interactions and are implicated...

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Source

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Identifiers

PMID: 28087981
DOI: 10.1002/jgm.2942
PMCID: PMC5382089

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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