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Article

CHSY1 promotes aggressive phenotypes of hepatocellular carcinoma cells via activation of the hedgehog signaling pathway.

Cancer letters - 10 Sept 2017

Liu Chiung-Hui, Lan Chyn-Tair, Chou Jui-Feng, Tseng To-Jung, Liao Wen-Chieh

Abstract excerpt

Abnormal expression of chondroitin sulfate has been found in many types of cancer, while its biological functions in hepatocellular carcinoma (HCC) progression remain uninvestigated. Here, we report that chondroitin sulfate synthase 1 (CHSY1), the enzyme that mediates the polymerization step of chondroitin sulfate, is a critical mediator of malignant character in HCC that acts via modulating the activity of the...

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Identifiers

PMID: 28652022
DOI: 10.1016/j.canlet.2017.06.023

Genes

CHSY1

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