Article
Parkin beyond Parkinson's Disease-A Functional Meaning of Parkin Downregulation in TDP-43 Proteinopathies.
Cells - 1 Dec 2021
Gaweda-Walerych Katarzyna, Sitek Emilia Jadwiga, Narożańska Ewa, Buratti Emanuele
Abstract excerpt
Parkin and PINK1 are key regulators of mitophagy, an autophagic pathway for selective elimination of dysfunctional mitochondria. To this date, parkin depletion has been associated with recessive early onset Parkinson's disease (PD) caused by loss-of-function mutations in the PARK2 gene, while, in sporadic PD, the activity and abundance of this protein can be compromised by stress-related modifications....
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