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Article

Metabolism and disposition of opicapone in the rat and metabolic enzymes phenotyping.

Pharmacology research & perspectives - 1 Feb 2022

Loureiro Ana I, Fernandes-Lopes Carlos, Bonifácio Maria João, Sousa Filipa, Kiss László E, Soares-da-Silva Patricio

Abstract excerpt

Opicapone (2,5-dichloro-3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-4,6-dimethylpyridine 1-oxide) is a selective catechol-O-methyltransferase inhibitor that has been granted marketing authorization in Europe, Japan, and United States. The present work describes the metabolism and disposition of opicapone in the rat obtained in support to its development and regulatory filling. Plasma levels and...

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PMID: 34939338
DOI: 10.1002/prp2.891
PMCID: PMC8929358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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