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DNA/RNA heteroduplex oligonucleotide technology for regulating lymphocytes in vivo

22 Dec 2021

Abstract excerpt

Manipulating lymphocyte functions with gene silencing approaches is promising for treating autoimmunity, inflammation, and cancer. Although oligonucleotide therapy has been proven to be successful in treating several conditions, efficient in vivo delivery of oligonucleotide to lymphocyte populations remains a challenge. Here, we demonstrate that intravenous injection of a heteroduplex oligonucleotide (HDO),...

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PMID: 34937876
DOI: 10.1038/s41467-021-26902-8

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