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Article

Antisense Oligonucleotide: Basic Concepts and Therapeutic Application in Inflammatory Bowel Disease

29 Mar 2019

Abstract excerpt

Antisense oligonucleotide (ASO) technology is a specific, rapid, and potentially high-throughput method for inhibiting gene expression. ASO refers to a short synthetic strand of deoxy-ribonucleotide analogue that hybridizes with the complementary mRNA via Watson–Crick base pairing. The resulting RNA-DNA heteroduplex leads to a reduced translation of the target transcript thus inducing a blockade in the transfer...

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PMID: 30983999
DOI: 10.3389/fphar.2019.00305

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