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Article

High-quality data from a forensically relevant single-cell pipeline enabled by low PBS and proteinase K concentrations.

Journal of forensic sciences - 1 Mar 2022

Sheth Nidhi, Duffy Ken R, Grgicak Catherine M

Abstract excerpt

Interpreting forensic DNA signal is arduous since the total intensity is a cacophony of signal from noise, artifact, and allele from an unknown number of contributors (NOC). An alternate to traditional bulk-processing pipelines is a single-cell one, where the sample is collected, and each cell is sequestered resulting in n single-source, single-cell EPGs (scEPG) that must be interpreted using applicable...

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PMID: 34936089
DOI: 10.1111/1556-4029.14956

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