Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Probabilistic genotyping of single cell replicates from complex DNA mixtures recovers higher contributor LRs than standard analysis.

Science & justice : journal of the Forensic Science Society - 1 Mar 2022

Huffman Kaitlin, Hanson Erin, Ballantyne Jack

Abstract excerpt

DNA mixtures are a common source of crime scene evidence and are often one of the more difficult sources of biological evidence to interpret. With the implementation of probabilistic genotyping (PG), mixture analysis has been revolutionized allowing previously unresolvable mixed profiles to be analyzed and probative genotype information from contributors to be recovered. However, due to allele overlap, artifacts,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA
Share to DNA Fingerprinting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Likelihood Functions

Share to Microsatellite Repeats

Source

Identifiers

PMID: 35277229
DOI: 10.1016/j.scijus.2022.01.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Probabilistic genotyping of single cell replicates from complex DNA mixtures recovers higher contributor LRs than standard analysis.PMID 35277229Read ↗

Cell Subsampling Recovers Probative DNA Profile Information from Unresolvable/Undetectable Minor Donors in Mixtures.Semantic proximity Read ↗

Carrying out common DNA donor analysis using DBLR™ on two or five-cell mini-mixture subsamples for improved discrimination power in complex DNA mixtures.Semantic proximity Read ↗

Precision DNA Mixture Interpretation with Single-Cell Profiling.Semantic proximity Read ↗

Probabilistic Genotyping of Single Cell Replicates from Mixtures Involving First-Degree Relatives Prevents the False Inclusions of Non-Donor Relatives.Semantic proximity Read ↗

Facilitating complex DNA mixture interpretation by sequencing highly polymorphic haplotypes.Semantic proximity Read ↗

Applications of Probabilistic Genotyping Method for Combining Evidence Across Microhaplotype DNA Mixture Profiles.Semantic proximity Read ↗

DNA mixture genotyping by probabilistic computer interpretation of binomially-sampled laser captured cell populations: combining quantitative data for greater identification information.Semantic proximity Read ↗

Single-cell investigative genetics: Single-cell data produces genotype distributions concentrated at the true genotype across all mixture complexities.Semantic proximity Read ↗

Internal Validation of MaSTR™ Probabilistic Genotyping Software for the Interpretation of 2-5 Person Mixed DNA Profiles.Semantic proximity Read ↗

Analysis of complex DNA mixtures using massively parallel sequencing of SNPs with low minor allele frequencies.Semantic proximity Read ↗

Validation of Probabilistic Genotyping Software for Single Cell STR Analysis.Semantic proximity Read ↗

MaSTR™: an effective probabilistic genotyping tool for interpretation of STR mixtures associated with differentially degraded DNA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.