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Article

Towards developing forensically relevant single-cell pipelines by incorporating direct-to-PCR extraction: compatibility, signal quality, and allele detection.

International journal of legal medicine - 1 May 2021

Sheth Nidhi, Swaminathan Harish, Gonzalez Amanda J, Duffy Ken R, Grgicak Catherine M

Abstract excerpt

Current analysis of forensic DNA stains relies on the probabilistic interpretation of bulk-processed samples that represent mixed profiles consisting of an unknown number of potentially partial representations of each contributor. Single-cell methods, in contrast, offer a solution to the forensic DNA mixture problem by incorporating a step that separates cells before extraction. A forensically relevant...

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PMID: 33484330
DOI: 10.1007/s00414-021-02503-4

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