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Article

Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALS.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Dec 2008

Suzuki Masatoshi, McHugh Jacalyn, Tork Craig, Shelley Brandon, Hayes Antonio, Bellantuono Ilaria, Aebischer Patrick, Svendsen Clive N

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which there is a progressive loss of motor neurons and their connections to muscle, leading to paralysis. In order to maintain muscle connections in a rat model of familial ALS (FALS), we performed intramuscular transplantation with human mesenchymal stem cells (hMSCs) used as "Trojan horses" to deliver growth factors to the terminals of...

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Source

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Identifiers

PMID: 18797452
DOI: 10.1038/mt.2008.197
PMCID: PMC2678899

Genes

GDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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