Article
Comparative biology of two genetically closely related Newcastle disease virus strains with strongly contrasting pathogenicity.
Veterinary microbiology - 1 Feb 2021
Chen Xi, Chen Siqi, Chen Haotian, Tian Jianxia, Zhao Xueliang, Jia Yanqing, Xiao Sa, Wang Xinglong, Liu Haijin, Yang Zengqi
Abstract excerpt
A lentogenic strain of Newcastle disease virus (NDV) with an intracerebral pathogenicity index (ICPI) of 0.36 was derived by the passage of a mesogenic NDV isolate with an original ICPI of 1.04. Animal experiments showed that the original strain caused much severer clinical signs and mortality th...
Topics
- Animals
- Cell Line
- Chick Embryo
- Chickens
- Cricetinae
- Genome, Viral
- Mutation
- Newcastle Disease
- Newcastle disease virus
- Poultry Diseases
- Specific Pathogen-Free Organisms
- Virulence
- Virus Replication