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Comparative biology of two genetically closely related Newcastle disease virus strains with strongly contrasting pathogenicity.

Veterinary microbiology - 1 Feb 2021

Chen Xi, Chen Siqi, Chen Haotian, Tian Jianxia, Zhao Xueliang, Jia Yanqing, Xiao Sa, Wang Xinglong, Liu Haijin, Yang Zengqi

Abstract excerpt

A lentogenic strain of Newcastle disease virus (NDV) with an intracerebral pathogenicity index (ICPI) of 0.36 was derived by the passage of a mesogenic NDV isolate with an original ICPI of 1.04. Animal experiments showed that the original strain caused much severer clinical signs and mortality than the derived strain in chickens. To elucidate the molecular reason for this virulence change, the complete viral...

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PMID: 33421684
DOI: 10.1016/j.vetmic.2020.108977

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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