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Article

The Large Polymerase Protein Is Associated with the Virulence of Newcastle Disease Virus

13 Jun 2008

Abstract excerpt

Naturally occurring Newcastle disease virus (NDV) strains vary greatly in virulence, ranging from no apparent infection to severe disease causing 100% mortality in chickens. The viral determinants of NDV virulence are not completely understood. Cleavage of the fusion protein is required for the initiation of infection, and it acts as a determinant of virulence. The attachment protein HN was found to play a minor...

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PMID: 18550657
DOI: 10.1128/jvi.00578-08

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The Large Polymerase Protein Is Associated with the Virulence of Newcastle Disease VirusPMID 18550657Read ↗

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Mutagenesis of the di-leucine motif in the cytoplasmic tail of newcastle disease virus fusion protein modulates the viral fusion ability and pathogenesis.Semantic proximity Read ↗

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Evaluation of the Contributions of Individual Viral Genes to Newcastle Disease Virus Virulence and PathogenesisSemantic proximity Read ↗

Screening and mechanistic study of key sites of the hemagglutinin-neuraminidase protein related to the virulence of Newcastle disease virusSemantic proximity Read ↗

The effect on pathogenesis of Newcastle disease virus LaSota strain from a mutation of the fusion cleavage site to a virulent sequence.Semantic proximity Read ↗

The M, F and HN genes of genotype VIId Newcastle disease virus are associated with the severe pathological changes in the spleen of chickensSemantic proximity Read ↗

A Y526Q Mutation in the Newcastle Disease Virus HN Protein Reduces Its Functional Activities and Attenuates Virus Replication and PathogenicitySemantic proximity Read ↗

Virulence of newcastle disease virus: what is known so far?Semantic proximity Read ↗

Contribution of the length of the HN protein and the sequence of the F protein cleavage site to Newcastle disease virus pathogenicitySemantic proximity Read ↗

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