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Article

Increase in the neuraminidase activity of a nonpathogenic Newcastle disease virus isolate during passaging in chickens.

The Journal of veterinary medical science - 1 Apr 2010

Tsunekun Ryota, Ito Hiroshi, Kida Hiroshi, Otsuki Koichi, Ito Toshihiro

Abstract excerpt

A pathogenic mutant of the Newcastle disease virus (NDV) was previously generated by passaging a non-pathogenic isolate from wild waterfowl. Velogenic mutant 9a5b (IVPI=2.67) contains three amino acid substitutions (128H, 495K and 573stop) in the hemagglutinin-neuraminidase (HN) protein, as compared with nonpathogenic waterfowl isolate 415/91 strain, and two of these (128H and 495K) were introduced after...

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Identifiers

PMID: 20009427
DOI: 10.1292/jvms.09-0474

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Increase in the neuraminidase activity of a nonpathogenic Newcastle disease virus isolate during passaging in chickens.PMID 20009427Read ↗

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