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Article

Increase in the neuraminidase activity of a nonpathogenic Newcastle disease virus isolate during passaging in chickens.

The Journal of veterinary medical science - 1 Apr 2010

Tsunekun Ryota, Ito Hiroshi, Kida Hiroshi, Otsuki Koichi, Ito Toshihiro

Abstract excerpt

A pathogenic mutant of the Newcastle disease virus (NDV) was previously generated by passaging a non-pathogenic isolate from wild waterfowl. Velogenic mutant 9a5b (IVPI=2.67) contains three amino acid substitutions (128H, 495K and 573stop) in the hemagglutinin-neuraminidase (HN) protein, as compared with nonpathogenic waterfowl isolate 415/91 strain, and two of these (128H and 495K) were introduced after...

Topics

Animals
Cell Line
Chickens
Cloning, Molecular
DNA Primers
Genetic Variation
HN Protein
Hemadsorption
Humans
Kidney
Neuraminidase
Newcastle Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Newcastle disease virus

Plasmids

Virulence

Source

Identifiers

PMID: 20009427
DOI: 10.1292/jvms.09-0474

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-20009427-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Increase in the neuraminidase activity of a nonpathogenic Newcastle disease virus isolate during passaging in chickens.PMID 20009427Read ↗

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