Article
Clinical feature-related single-base substitution sequence signatures identified with an unsupervised machine learning approach.
BMC medical genomics - 20 Dec 2021
Ji Hongchen, Li Junjie, Zhang Qiong, Yang Jingyue, Duan Juanli, Wang Xiaowen, Ma Ben, Zhang Zhuochao, Pan Wei, Zhang Hongmei
Abstract excerpt
BACKGROUND: Mutation processes leave different signatures in genes. For single-base substitutions, previous studies have suggested that mutation signatures are not only reflected in mutation bases but also in neighboring bases. However, because of the lack of a method to identify features of long sequences next to mutation bases, the understanding of how flanking sequences influence mutation signatures is...
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