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Article

Pathogenicity of SARS-CoV-2 Omicron Subvariants JN.1, KP.2, and EG.5.1 in K18-hACE2 Transgenic Mice.

Viruses - 28 Aug 2025

Patterson Lila D, Elsharkawy Amany, Jahantigh Hamid Reza, Nabi Zainab, Stone Shannon, Kumar Mukesh

Abstract excerpt

The emergence of the SARS-CoV-2 JN.1 lineage in late 2023 marked a major shift in viral evolution. By January 2024, it had displaced XBB variants to become the dominant strain worldwide. JN.1 and its descendants are antigenically distinct from earlier Omicron subvariants, with approximately 30 additional spike mutations compared to XBB-derived viruses. The combination of these features alongside growing evidence...

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Identifiers

PMID: 41012604
DOI: 10.3390/v17091177
PMCID: PMC12474420

Genes

ACE2

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