Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic association study using GWAS and Mendelian randomization to central nervous system comorbidities between multisite chronic pain and major depressive disorder.

Behavioural brain research - 5 Aug 2026

Li Shinan, Liu Aihui, Jiang Hongyang, Ying Zhenhua

Abstract excerpt

BACKGROUND: Multisite chronic pain (MCP) and major depressive disorder (MDD) exhibit significant clinical relevance. However, the central nervous system comorbidity mechanism and the shared genetic risk mechanisms remain poorly elucidated. This study aims to systematically investigate the neurobiological and genetic correlation features between MCP and MDD. METHOD: Leveraging a multidimensional genetic framework,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Pain
Share to Comorbidity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DCC gene

Share to TCF4 gene

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Major Depressive Disorder

Share to Mendelian Randomization Analysis

Source

Identifiers

PMID: 42119900
DOI: 10.1016/j.bbr.2026.116189

Genes

DCC
PGC
TCF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic association study using GWAS and Mendelian randomization to central nervous system comorbidities between multisite chronic pain and major depressive disorder.PMID 42119900Read ↗

Identification of novel common variants associated with chronic pain using conditional false discovery rate analysis with major depressive disorder and assessment of pleiotropic effects of LRFN5.Semantic proximity Read ↗

Genome-wide association study of multisite chronic pain in UK BiobankSemantic proximity Read ↗

Reciprocal interaction between depression and pain: results from a comprehensive bidirectional Mendelian randomization study and functional annotation analysis.Semantic proximity Read ↗

Genetic and Environmental Risk for Chronic Pain and the Contribution of Risk Variants for Major Depressive Disorder: A Family-Based Mixed-Model AnalysisSemantic proximity Read ↗

Identify novel, shared and disorder-specific genetic architecture of major depressive disorder, insomnia and chronic pain.Semantic proximity Read ↗

Genetic risk shared across 24 chronic pain conditions: identification and characterization with genomic structural equation modelingSemantic proximity Read ↗

Symptoms of depression in chronic pain: prevalence in UK Biobank and shared genetic factorsSemantic proximity Read ↗

A shared genetic signature for common chronic pain conditions and its impact on biopsychosocial traitsSemantic proximity Read ↗

A Shared Genetic Signature for Common Chronic Pain Conditions and its Impact on Biopsychosocial Traits.Semantic proximity Read ↗

GWAS Meta-Analysis Reveals Shared Genes and Biological Pathways Between Major Depressive Disorder and InsomniaSemantic proximity Read ↗

Phenome-wide investigation of bidirectional causal relationships between major depressive disorder and common human diseases.Semantic proximity Read ↗

Overlapping common genetic architecture between major depressive disorders and anxiety and stress-related disorders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.