Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Origins of Merkel Cell Carcinoma: Defining Paths to the Neuroendocrine Phenotype.

The Journal of investigative dermatology - 1 Mar 2022

Tsai Kenneth Y

Abstract excerpt

Two recent reports leverage careful genomic analysis to show that human Merkel cell carcinomas (MCCs) arising from squamous cell carcinoma in situ bear hallmarks of genetic relatedness, suggesting that a subset of MCCs can arise from pre-existing intraepithelial keratinocytic proliferations in human skin. This has important implications for our understanding of cells of origin and the diverse drivers of MCC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma in Situ
Share to Carcinoma, Merkel Cell
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Phenotype

Share to Skin Neoplasms

Source

Identifiers

PMID: 34924186
DOI: 10.1016/j.jid.2021.11.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Origins of Merkel Cell Carcinoma: Defining Paths to the Neuroendocrine Phenotype.PMID 34924186Read ↗

Merkel Cell Polyomavirus‒Negative Merkel Cell Carcinoma Originating from In Situ Squamous Cell Carcinoma: A Keratinocytic Tumor with Neuroendocrine DifferentiationSemantic proximity Read ↗

The complex conundrum of Merkel cell carcinoma cellular ancestrySemantic proximity Read ↗

Transcriptomic analyses reveal three distinct molecular subgroups of Merkel cell carcinoma with differing prognosesSemantic proximity Read ↗

Reviewing the current evidence supporting early B-cells as the cellular origin of Merkel cell carcinomaSemantic proximity Read ↗

Merkel cell carcinoma: an updated overview of clinico-pathological aspects, molecular genetics and therapy.Semantic proximity Read ↗

Molecular Pathogenesis of Merkel Cell Carcinoma.Semantic proximity Read ↗

Histogenesis of Merkel Cell Carcinoma: A Comprehensive ReviewSemantic proximity Read ↗

Merkel cell carcinoma in southern China: clinicopathologic and transcriptomic analysis with insights into an intraepidermal-predominant lesionSemantic proximity Read ↗

Danger is only skin deep: aggressive epidermal carcinomas. An overview of the diagnosis, demographics, molecular-genetics, staging, prognostic biomarkers, and therapeutic advances in Merkel cell carcinoma.Semantic proximity Read ↗

DNA-methylation patterns imply a common cellular origin of virus- and UV-associated Merkel cell carcinomaSemantic proximity Read ↗

Genetic Risk Factors for Early-Onset Merkel Cell Carcinoma.Semantic proximity Read ↗

Which Are the Cells of Origin in Merkel Cell Carcinoma?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.