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Histogenesis of Merkel Cell Carcinoma: A Comprehensive Review

10 Jun 2019

Abstract excerpt

Merkel cell carcinoma (MCC) is a primary neuroendocrine carcinoma of the skin. This neoplasia features aggressive behavior, resulting in a 5-year overall survival rate of 40%. In 2008, Feng et al. identified Merkel cell polyomavirus (MCPyV) integration into the host genome as the main event leading to MCC oncogenesis. However, despite identification of this crucial viral oncogenic trigger, the nature of the cell...

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PMID: 31245285
DOI: 10.3389/fonc.2019.00451

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