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Elevated plasma complement components in facioscapulohumeral dystrophy

16 Dec 2021

Abstract excerpt

Advances in understanding the pathophysiology of facioscapulohumeral dystrophy (FSHD) have led to several therapeutic approaches entering clinical trials and an increased need to develop biomarkers of disease activity and progression. Multiple prior studies have shown early elevation of RNAs encoding components of the complement pathways and relatively widespread activated complement complexes by immunodetection...

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PMID: 34919696
DOI: 10.1093/hmg/ddab364

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