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A Targeted Approach for Evaluating DUX4-Regulated Proteins as Potential Serum Biomarkers for Facioscapulohumeral Muscular Dystrophy Using Immunoassay Proteomics

2022-07-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Facioscapulohumeral muscular dystrophy (FSHD) is a progressive myopathy caused by misexpression of the double homeobox 4 (DUX4) embryonic transcription factor in skeletal muscle. Identifying quantitative and minimally invasive FSHD biomarkers to report on DUX4 activity will significantly accelerate therapeutic development. <h4>Objective</h4> The goal of this study was to analy...

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Literature Corpus work: 87895781-c3ae-500b-9c87-29e18e092a4a
DOI: 10.1101/2022.07.25.22276982

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