Article

A human immune/muscle xenograft model of FSHD muscle pathology

2023-11-17

Abstract excerpt

<h4>Background</h4> Facioscapulohumeral muscular dystrophy (FSHD) disease progression is associated with muscle inflammation, although its role in FSHD muscle pathology is unknown. <h4>Methods</h4> We have developed a novel humanized mouse strain, NSG-SGM3-W41, that supports the co- engraftment of human hematopoietic stem cells (HSCs) and muscle myoblasts as an experimental model to investigate the role of innat...

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Literature Corpus work: 3022e27c-674c-5ad9-8fff-f4cecbdc62fa
DOI: 10.1101/2023.11.17.567590

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