An HIV Vaccine Protective Allele in FCGR2C Associates With Increased Odds of Perinatal HIV Acquisition.

doi:10.3389/fimmu.2021.760571

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

An HIV Vaccine Protective Allele in FCGR2C Associates With Increased Odds of Perinatal HIV Acquisition.

Frontiers in immunology - 1 Jan 2021

Ebonwu Joy, Lassaunière Ria, Paximadis Maria, Goosen Mark, Strehlau Renate, Gray Glenda E, Kuhn Louise, Tiemessen Caroline T

Abstract excerpt

In the Thai RV144 HIV-1 vaccine trial, a three-variant haplotype within the Fc gamma receptor 2C gene (FCGR2C) reduced the risk of HIV-1 acquisition. A follow-on trial, HVTN702, of a similar vaccine candidate found no efficacy in South Africa, where the predominant population is polymorphic for only a single variant in the haplotype, c.134-96C>T (rs114945036). To investigate a role for this variant in HIV-1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Copy Number Variations

Share to HIV-1

Share to HIV Infections

Share to Infant, Newborn

Share to Infectious Disease Transmission, Vertical

Share to Randomized Controlled Trials as Topic

Share to Receptors, IgG

Source

Open in PubMed Open full text

Identifiers

PMID: 34917081
DOI: 10.3389/fimmu.2021.760571
PMCID: PMC8668943

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An HIV Vaccine Protective Allele in FCGR2C Associates With Increased Odds of Perinatal HIV Acquisition.PMID 34917081Read ↗

FCGR2C Polymorphisms Associated with HIV-1 Vaccine Protection Are Linked to Altered Gene Expression of Fc-γ Receptors in Human B Cells.Semantic proximity Read ↗

FCGR2C polymorphisms associate with HIV-1 vaccine protection in RV144 trial.Semantic proximity Read ↗

FcγR Genetic Variation and HIV-1 Vaccine Efficacy: Context And Considerations.Semantic proximity Read ↗

IgG and Fc Receptor Genetic Variation Associates With Functional Antibody Responses in a DNA and Protein Candidate HIV Vaccine Trial.Semantic proximity Read ↗

Polymorphisms in TH1-TH2 cytokine and receptor genes associated with risk of vertical HIV transmission, in Mumbai, India.Semantic proximity Read ↗

Perinatal HIV-1 transmission: Fc gamma receptor variability associates with maternal infectiousness and infant susceptibility.Semantic proximity Read ↗

KIR-HLA and maternal-infant HIV-1 transmission in sub-Saharan Africa.Semantic proximity Read ↗

Safety and implementation of a phase 1 randomized GLA-SE-adjuvanted CH505TF gp120 HIV vaccine trial in newbornsSemantic proximity Read ↗

Influence of intragenic CCL3 haplotypes and CCL3L copy number in HIV-1 infection in a sub-Saharan African population.Semantic proximity Read ↗

V1V2-specific complement activating serum IgG as a correlate of reduced HIV-1 infection risk in RV144Semantic proximity Read ↗

Prevalence and correlates of GB virus C infection in HIV-infected and HIV-uninfected pregnant women in Bangkok, Thailand.Semantic proximity Read ↗

Functional genetic variants in DC-SIGNR are associated with mother-to-child transmission of HIV-1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.