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Article

CLOCK Genetic Variations Are Associated With Age-Related Changes in Sleep Duration and Brain Volume.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Sept 2022

Kim Song E, Kim Soriul, Kim Hyeon-Jin, Kim Regina Eun-Young, Kim Sol-Ah, Shin Chol, Lee Hyang Woon

Abstract excerpt

BACKGROUND: Although a connection between sleep disruption and brain aging has been documented, biological mechanisms need to be further clarified. Intriguingly, aging is associated with circadian rhythm and/or sleep dysfunction in a key gene regulating circadian rhythm, Circadian Locomotor Output Cycles Kaput (CLOCK), has been linked to both aging-related sleep disturbances and neurodegenerative diseases. This...

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Identifiers

PMID: 34908110
DOI: 10.1093/gerona/glab365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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