Article

Genetically mediated associations between chronotype and neuroimaging phenotypes in the UK Biobank: a Mendelian randomisation study

2023-09-03

Abstract excerpt

Chronotype impacts numerous physiological and disease traits, from metabolic syndrome to schizophrenia. The suprachiasmatic nucleus (SCN) maintains transcriptional-translational feedback loop (TTFL) which acts as a central chronobiological pacemaker, regulating 24-hour cycles throughout the human body. However, each tissue maintains its own peripheral clock, and both endogenous hormones and neurotransmitters and e...

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Literature Corpus work: ec0f0af0-3bfd-5392-8e5c-cb621ebe84d5
DOI: 10.1101/2023.08.31.555801

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