Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Persistence of SIV in the brain of SIV-infected Chinese rhesus macaques with or without antiretroviral therapy.

Journal of neurovirology - 1 Feb 2018

Perez Stefanie, Johnson Ann-Marie, Xiang Shi-Hua, Li Jian, Foley Brian T, Doyle-Meyers Lara, Panganiban Antonito, Kaur Amitinder, Veazey Ronald S, Wu Yuntao, Ling Binhua

Abstract excerpt

Persistence of HIV-1 reservoirs in the central nervous system (CNS) is an obstacle to cure strategies. However, little is known about residual viral distribution, viral replication levels, and genetic diversity in different brain regions of HIV-infected individuals on combination antiretroviral therapy (cART). Because myeloid cells particularly microglia are likely major reservoirs in the brain, and more...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basal Ganglia
Share to Brain Stem

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gray Matter

Share to HIV Envelope Protein gp120

Share to Macaca mulatta

Share to Simian Acquired Immunodeficiency Syndrome

Share to Simian Immunodeficiency Virus

Share to White Matter

Source

Open in PubMed Open full text

Identifiers

PMID: 29181724
DOI: 10.1007/s13365-017-0594-0
PMCID: PMC5792315

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Persistence of SIV in the brain of SIV-infected Chinese rhesus macaques with or without antiretroviral therapy.PMID 29181724Read ↗

Microglia and macrophages alterations in the CNS during acute SIV infection: A single-cell analysis in rhesus macaquesSemantic proximity Read ↗

Microglia and macrophages alterations in the CNS during acute SIV infection: a single-cell analysis in rhesus macaquesSemantic proximity Read ↗

Opioid-induced immunosuppression of brain myeloid cells in SIV-infected rhesus macaquesSemantic proximity Read ↗

Lentiviral Infections Persist in Brain despite Effective Antiretroviral Therapy and Neuroimmune Activation.Semantic proximity Read ↗

The central nervous system as a reservoir for simian immunodeficiency virus (SIV): steady-state levels of SIV DNA in brain from acute through asymptomatic infection.Semantic proximity Read ↗

Microglia Exhibit a Unique Intact HIV Reservoir in Human Postmortem Brain TissueSemantic proximity Read ↗

Dynamics of simian immunodeficiency virus populations in blood and cerebrospinal fluid over the full course of infection.Semantic proximity Read ↗

Reactivation of simian immunodeficiency virus reservoirs in the brain of virally suppressed macaquesSemantic proximity Read ↗

Laser Capture Microdissection Assessment of Virus Compartmentalization in the Central Nervous Systems of Macaques Infected with Neurovirulent Simian Immunodeficiency VirusSemantic proximity Read ↗

Phylogenetics and Phyloanatomy of HIV/SIV Intra-Host Compartments and Reservoirs: The Key Role of the Central Nervous SystemSemantic proximity Read ↗

Initiation of antiretroviral therapy during chronic SIV infection leads to rapid reduction in viral loads and the level of T-cell immune response.Semantic proximity Read ↗

HIV-1 promotes cell-to-cell interactions enabling spread from CD4+ T cells to microgliaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.