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Article

A single mutation in the PrM gene of Zika virus determines AXL dependency for infection of human neural cells.

Journal of virology - 15 Apr 2025

Khasa Renu, Ogden Sarah C, Wang Yuqing, Mou Zongiun, Metzler Anna D, Xie Xuping, Dai Xinghong, Tang Hengli

Abstract excerpt

Zika virus (ZIKV) is spread by mosquito bites and is unique among known flaviviruses for being able to cause microcephaly. Entry factors for ZIKV are incompletely understood, but phosphatidylserine (PS) receptors, including the TAM (Tyro3, AXL, and Mer) and TIM (T-cell Ig mucin) families, can serve as cofactors for flavivirus entry in a cell type-specific manner. We identify AXL as the top hit in a CRISPR/Cas9...

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Share to Axl Receptor Tyrosine Kinase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40062839
DOI: 10.1128/jvi.01873-24
PMCID: PMC11998517

Genes

AXL
TYRO3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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