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Genetically modified ZIKA virus as a microRNA-sensitive oncolytic virus against central nervous system tumors

11 Jan 2024

Abstract excerpt

Here we introduce a first-in-class microRNA-sensitive oncolytic Zika virus (ZIKV) for virotherapy application against central nervous system (CNS) tumors. The described methodology produced two synthetic modified ZIKV strains that are safe in normal cells, including neural stem cells, while preserving brain tropism and oncolytic effects in tumor cells. The microRNA-sensitive ZIKV introduces genetic modifications...

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PMID: 38213031
DOI: 10.1016/j.ymthe.2024.01.006

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