Article
A Promising Mouse Model of Graves' Orbitopathy Induced by Adenovirus Expressing Thyrotropin Receptor A Subunit.
Thyroid : official journal of the American Thyroid Association - 1 Apr 2021
Zhang Meng, Ding Xi, Wu Li-Ping, He Ming-Qian, Chen Zi-Yi, Shi Bing-Yin, Wang Yue
Abstract excerpt
Background: Graves' orbitopathy (GO) is the most common and serious manifestation of Graves' disease (GD). It is characterized by orbital inflammation and tissue remodeling. Although several GO models have been reported, most lack a full assessment or mechanistic evaluation. Here, we established a promising mouse model mimicking many aspects of human GO with a frequency of 70% and characterized the key role of T...
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